Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis

@article{Malnsk2009IncreasedLO,
  title={Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis},
  author={Hana Mal{\'i}nsk{\'a} and Olena Oliyarnyk and Miriam Hubov{\'a} and V{\'a}clav Z{\'i}dek and Vladim{\'i}r Landa and Miroslava {\vS}im{\'a}kov{\'a} and Petr Mlejnek and Ludmila Kazdov{\'a} and Theodore W. Kurtz and Michal Pravenec},
  journal={Molecular and Cellular Biochemistry},
  year={2009},
  volume={335},
  pages={119-125}
}
The temporal relationship of hepatic steatosis and changes in liver oxidative stress and fatty acid (FA) composition to the development of non-alcoholic steatohepatitis (NASH) remain to be clearly defined. Recently, we developed an experimental model of hepatic steatosis and NASH, the transgenic spontaneously hypertensive rat (SHR) that overexpresses a dominant positive form of the human SREBP-1a isoform in the liver. These rats are genetically predisposed to hepatic steatosis at a young age… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 15 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

The epidemiology of nonalcoholic fatty liver disease in adults

  • JM Clark
  • J Clin Gastroenterol
  • 2006
1 Excerpt

Similar Papers

Loading similar papers…