Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice.

@article{Donnelly2004IncreasedLA,
  title={Increased lipogenesis and fatty acid reesterification contribute to hepatic triacylglycerol stores in hyperlipidemic Txnip-/- mice.},
  author={Kerry L Donnelly and Mark R Margosian and Sonal S. Sheth and Aldons J. Lusis and Elizabeth J Parks},
  journal={The Journal of nutrition},
  year={2004},
  volume={134 6},
  pages={1475-80}
}
The effect of decreased fatty acid oxidation on liver lipid metabolism in HcB-19 mice, a mouse model of hyperlipidemia (Txnip(-/-)), was investigated using metabolic labeling. De novo cholesterol synthesis and de novo lipogenesis were quantified using 1-(13)C(1) acetic acid, and liver triacylglycerol (TAG) derived from dietary fatty acids was quantified using dietary glyceryl tri(hexandecanoate-d(31)). Tissue samples were analyzed for TAG, free cholesterol (FC), and cholesterol ester (CE… CONTINUE READING

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