Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration.

@article{Gerrits2006IncreasedLP,
  title={Increased limbic phosphorylated extracellular-regulated kinase 1 and 2 expression after chronic stress is reduced by cyclic 17beta-estradiol administration.},
  author={Marjolein Gerrits and Christel Westenbroek and Tineke Koch and A Grootkarzijn and Gert J. ter Horst},
  journal={Neuroscience},
  year={2006},
  volume={142 4},
  pages={1293-302}
}
Chronic stress induced neuronal changes that may have consequences for subsequent stress responses. For example, chronic stress in rats rearranges dendritic branching patterns and disturbs the phosphorylation of extracellular-regulated kinase 1 and 2 (ERK) 1/2 throughout the limbic system. Stress-induced psychopathology occurs more often in women, however, most of studies have been done in male rats. Therefore, we studied the effect of stress in female rats. Other studies show that estradiol… CONTINUE READING

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