Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

@inproceedings{Cabreiro2011IncreasedLS,
  title={Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage},
  author={Filipe Cabreiro and Daniel Ackerman and Ryan Doonan and Caroline Araiz and Patricia Back and Diana Papp and Bart P. Braeckman and David Gems},
  booktitle={Free radical biology & medicine},
  year={2011}
}
The superoxide free radical (O(2)(•-)) has been viewed as a likely major contributor to aging. If this is correct, then superoxide dismutase (SOD), which removes O(2)(•-), should contribute to longevity assurance. In Caenorhabditis elegans, overexpression (OE) of the major cytosolic Cu/Zn-SOD, sod-1, increases life span. But is this increase caused by enhanced antioxidant defense? sod-1 OE did not reduce measures of lipid oxidation or glycation and actually increased levels of protein oxidation… CONTINUE READING
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Effects of sod gene overexpression and deletion mutation on the expression pro fi les of reporter genes of major detoxi fi cation pathways in Caenorhabditis elegans

  • K. Yasuda, H. Adachi, Y. Fujiwara, N. Ishii
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