Increased levels of vascular endothelial cell markers in thrombotic thrombocytopenic purpura.

@article{Wada1993IncreasedLO,
  title={Increased levels of vascular endothelial cell markers in thrombotic thrombocytopenic purpura.},
  author={Hideo Wada and Toshihiro Kaneko and Mikinao Ohiwa and Masahiko Tanigawa and Tomoshige Hayashi and Shigehisa Tamaki and Nobuyuki Minami and Kazushi Deguchi and Kenshi Suzuki and Takeshi Nakano},
  journal={American journal of hematology},
  year={1993},
  volume={44 2},
  pages={
          101-5
        }
}
We found that patients with thrombotic thrombocytopenic purpura (TTP) have significantly elevated plasma thrombin antithrombin III complex (TAT) and FDP-D-dimer levels, while the plasmin-alpha 2 plasmin inhibitor complex (PIC) level was only slightly increased. The tissue-type plasminogen activator (t-PA) level was increased, but it was well correlated with the plasminogen activator inhibitor-I (PAI-I) level. These findings suggest that hypercoagulable and hypofibrinolytic states coexist in… CONTINUE READING

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