Increased levels of tumor necrosis factor and interleukin 1 in bronchoalveolar lavage fluids from pigs infected with Mycoplasma hyopneumoniae.

@article{Asai1993IncreasedLO,
  title={Increased levels of tumor necrosis factor and interleukin 1 in bronchoalveolar lavage fluids from pigs infected with Mycoplasma hyopneumoniae.},
  author={Tetsuo Asai and Munenori Okada and Masaaki Ono and T Irisawa and Yasuyuki Mori and Yuichi Yokomizo and Sunao Sato},
  journal={Veterinary immunology and immunopathology},
  year={1993},
  volume={38 3-4},
  pages={253-60}
}
We examined the levels of tumor necrosis factor (TNF)-alpha and interleukin-1 (IL-1) in bronchoalveolar lavage fluids (BALF) from pigs experimentally infected with Mycoplasma hyopneumoniae using biological assays with WEHI-164 cells and D10.G4.1 cells, respectively. Increased TNF-alpha and IL-1 in BALF were found in infected pigs with gross and/or microscopic lesions. A time-course study suggested TNF-alpha and IL-1 to be persistently elevated in infected pigs. Their presence in BALF would thus… CONTINUE READING