Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease.

@article{Lindner1993IncreasedLO,
  title={Increased levels of truncated nerve growth factor receptor in urine of mildly demented patients with Alzheimer's disease.},
  author={Mark D. Lindner and Dr. David Gordon and Jeffrey M. Miller and Pierre N. Tariot and Kristen Mcdaniel and Robert Hamill and Peter S Distefano and Rebekah Loy},
  journal={Archives of neurology},
  year={1993},
  volume={50 10},
  pages={1054-60}
}
OBJECTIVE In Alzheimer's disease, cholinergic basal forebrain neurons, which have receptors for nerve growth factor (NGF), degenerate, while NGF receptors increase in some areas of the neocortex. Levels of the truncated, extracellular portion of the NGF receptor (NGF-Rt) are elevated in urine of patients with peripheral neuropathies and in animals with peripheral-nerve injury, but it has not been determined whether urine levels of NGF-Rt are altered by the presence and/or progression of… CONTINUE READING

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Current Clinical Neurology • 2000

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