Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises

@inproceedings{Krishnan2010IncreasedLO,
  title={Increased levels of the inflammatory biomarker C-reactive protein at baseline are associated with childhood sickle cell vasocclusive crises},
  author={Suba Krishnan and Yamaja B. N. Setty and Suhita Gayen Betal and Vaidyula Vijender and K Phanidhara Rao and Carlton Dampier and Marie J. Stuart},
  booktitle={British journal of haematology},
  year={2010}
}
Several lines of evidence suggest that sickle cell disease (SCD) is associated with a chronic inflammatory state. In this study of 70 children with SCD at steady state evaluated by a broad panel of biomarkers representing previously examined mechanisms of pathogenicity in SCD, high sensitivity C-reactive protein (hs-CRP), a marker of low-grade, systemic inflammation, emerged as the most significant laboratory correlate of hospitalizations for pain or vaso-occlusive (VOC) events. While markers… CONTINUE READING
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