Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD.

@article{Traves2002IncreasedLO,
  title={Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD.},
  author={Suzanne L. Traves and Sarah V. Culpitt and Richard E K Russell and Peter J Barnes and Louise E Donnelly},
  journal={Thorax},
  year={2002},
  volume={57 7},
  pages={
          590-5
        }
}
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) have increased numbers of neutrophils and macrophages in their lungs. Growth related oncogene-alpha (GROalpha) attracts neutrophils, whereas monocyte chemoattractant protein-1 (MCP-1) attracts monocytes that can differentiate into macrophages. The aim of this study was to determine the concentration of GROalpha and MCP-1 in bronchoalveolar lavage (BAL) fluid and sputum from non-smokers, healthy smokers and patients with COPD… CONTINUE READING
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