Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice.

@article{Kalin2006IncreasedLO,
  title={Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice.},
  author={Tanya V Kalin and I -J Wang and Timothy J Ackerson and Michael L. Major and Carol J Detrisac and Vladimir V Kalinichenko and Alexander Lyubimov and Robert H. Costa},
  journal={Cancer research},
  year={2006},
  volume={66 3},
  pages={1712-20}
}
The proliferation-specific Forkhead Box M1 (FoxM1 or FoxM1b) transcription factor is overexpressed in a number of aggressive human carcinomas. Mouse hepatocytes deficient in FoxM1 fail to proliferate and are highly resistant to developing carcinogen-induced liver tumors. We previously developed a transgenic (TG) mouse line in which the ubiquitous Rosa26 promoter was used to drive expression of the human FoxM1b cDNA transgene in all mouse cell types. To investigate the role of FoxM1b in prostate… CONTINUE READING
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