Increased levels of superoxide in brains from old female rats.

  title={Increased levels of superoxide in brains from old female rats.},
  author={Daniel Antier and Hilary V O Carswell and Mary Julia Brosnan and Carlene A. Hamilton and I Mhairi Macrae and Samantha Groves and Emma Jardine and John L. Reid and Anna E Dominiczak},
  journal={Free radical research},
  volume={38 2},
Hypertension, aging and a range of neurodegenerative diseases are associated with increased oxidative damage. The present study examined whether superoxide (O2*-) levels in brain are increased during aging in female rats, and the role of superoxide dismutase (SOD) and oestrogen in regulating O2*- levels. Young adult (3 month) and old (11 month) female spontaneously hypertensive stroke prone rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY) were studied. O2*- levels were measured in brain… CONTINUE READING