Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.

@article{Cope1992IncreasedLO,
  title={Increased levels of soluble tumor necrosis factor receptors in the sera and synovial fluid of patients with rheumatic diseases.},
  author={Andrew P Cope and Dan Aderka and Michael Thomas Doherty and Hartmut Engelmann and Deena L Gibbons and Adrian Jones and Fionula Mary Brennan and Ravinder Nath Maini and David Wallach and Matthew Lincoln Feldmann},
  journal={Arthritis and rheumatism},
  year={1992},
  volume={35 10},
  pages={
          1160-9
        }
}
OBJECTIVE Recently, 2 classes of cytokine inhibitors have been defined at the molecular level. The largest group comprises the extracellular domains of cell surface cytokine receptors, and includes both tumor necrosis factor receptors (TNF-R). The present study was conducted to investigate the role of TNF inhibitors in arthritis. METHODS We measured p55 and p75 soluble TNF-R (sTNF-R) in serum and synovial fluid (SF) samples from patients with rheumatic diseases and compared their levels with… CONTINUE READING
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