Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction.

@article{Deffieu2013IncreasedLO,
  title={Increased levels of reduced cytochrome b and mitophagy components are required to trigger nonspecific autophagy following induced mitochondrial dysfunction.},
  author={Maika Deffieu and Ingrid Bhatia-Ki{\vs}{\vs}ov{\'a} and B{\'e}n{\'e}dicte Salin and Daniel J Klionsky and Beno{\^i}t Pinson and St{\'e}phen Manon and Nadine Camougrand},
  journal={Journal of cell science},
  year={2013},
  volume={126 Pt 2},
  pages={
          415-26
        }
}
Mitochondria are essential organelles producing most of the energy required for the cell. A selective autophagic process called mitophagy removes damaged mitochondria, which is critical for proper cellular homeostasis; dysfunctional mitochondria can generate excess reactive oxygen species that can further damage the organelle as well as other cellular components. Although proper cell physiology requires the maintenance of a healthy pool of mitochondria, little is known about the mechanism… CONTINUE READING

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