Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil

@article{Haeusler1979IncreasedLO,
  title={Increased levels of prostaglandin-like material in the canine blood during arterial hypotension produced by hydralazine, dihydralazine and minoxidil},
  author={Guenther Haeusler and Marcel Gerold},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1979},
  volume={310},
  pages={155-167}
}
Summary1.Indomethacin completely reversed within 15 min the hypotension produced by hydralazine or dihydralazine in anaesthetized dogs. Acetylsalicylic acid, diclofenac sodium and flufenamic acid inhibitors of prostaglandin synthesis structurally dissimilar to indomethacin — had the same effect. Pretreatment of anaesthetized dogs with indomethacin prevented in part the hypotension in response to a subsequent injection of hydralazine.2.The development of hypotension in response to hydralazine or… CONTINUE READING

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Indomethacin does not attenuate the effects of hydralazine in normal subjects

  • European Journal of Clinical Pharmacology
  • 1983
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Hydralazine inhibits human peritoneal mesothelial cell proliferation and collagen synthesis.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 1996
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