Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.

@article{Horikiri2017IncreasedLO,
  title={Increased levels of prostaglandin E-major urinary metabolite (PGE-MUM) in chronic fibrosing interstitial pneumonia.},
  author={Tsugumi Horikiri and Hiromichi Hara and Nayuta Saito and Jun Araya and Naoki Takasaka and Hirofumi Utsumi and Haruhiko Yanagisawa and Mitsuo Hashimoto and Yutaka Yoshii and Hiroshi Wakui and Shunsuke Minagawa and Takeo Ishikawa and Kenichiro Shimizu and Takanori Numata and Seiji Arihiro and Yumi Kaneko and Katsutoshi Nakayama and Tomokazu Matsuura and Masaaki Matsuura and Mutsunori Fujiwara and Isao Okayasu and Satoru Ito and Kazuyoshi Kuwano},
  journal={Respiratory medicine},
  year={2017},
  volume={122},
  pages={43-50}
}
BACKGROUND Dysregulation of the prostaglandin E2 (PGE2) signaling pathway has been implicated in interstitial pneumonia (IP) pathogenesis. Due to the unstable nature of PGE2, available detection methods may not precisely reflect PGE2 levels. We explored the clinical usefulness of measuring stable prostaglandin E-major urinary metabolite (PGE-MUM) with respect to pathogenesis and extent of chronic fibrosing IP (CFIP), including idiopathic pulmonary fibrosis (IPF), as PGE-MUM is reflective of… CONTINUE READING