Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study.

@article{Dexter1994IncreasedLO,
  title={Increased levels of lipid hydroperoxides in the parkinsonian substantia nigra: an HPLC and ESR study.},
  author={David T Dexter and Alan E. Holley and William D. Flitter and Trevor F. Slater and Fiona Wells and SusanE. Daniel and A. J. Lees and Patricia Jenner and Cd. Marsden},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={1994},
  volume={9 1},
  pages={
          92-7
        }
}
Previous studies examining the involvement of oxidative stress in the substantia nigra in Parkinson's disease have measured terminal products of lipid peroxidation or the function of antioxidant defense systems. We report a more specific early marker of lipid peroxidation, lipid hydroperoxides, in a high-performance liquid chromatography (HPLC) and electron spin resonance (ESR) investigation. HPLC-chemiluminescent detection revealed two classes of lipid hydroperoxides in brain tissue extracts… CONTINUE READING
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