Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice

@inproceedings{Pelosi2015IncreasedLO,
  title={Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice},
  author={Laura Pelosi and Maria Grazia Berardinelli and Laura Forcina and E. J. H. Spelta and Emanuele Rizzuto and Carmine Nicoletti and Carlotta Camilli and Erika Testa and Angela Catizone and Fabrizio De Benedetti and Antonio Musar{\`o}},
  booktitle={Human molecular genetics},
  year={2015}
}
Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the affected muscles of adult mdx mice rapidly regenerates and regains structural and functional integrity. The basis for the mild effects observed in mice compared with the lethal consequences in humans remains unknown. In this study, we provide… CONTINUE READING
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