Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.

@article{Arnold2016IncreasedLO,
  title={Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.},
  author={Kelly B. Arnold and Adam D Burgener and Kenzie Birse and Laura M. Romas and Laura J Dunphy and Kamnoosh Shahabi and Max C Abou and Garrett Westmacott and Stuart J. McCorrister and Jessie K L Kwatampora and Billy Nyanga and Joshua Kimani and Lindi Masson and Lenine J Liebenberg and Salim S Abdool Karim and Jo-Ann S Passmore and Douglas A. Lauffenburger and Rupert Kaul and Lyle R McKinnon},
  journal={Mucosal immunology},
  year={2016},
  volume={9 1},
  pages={194-205}
}
Elevated inflammatory cytokines (EMCs) at mucosal surfaces have been associated with HIV susceptibility, but the underlying mechanisms remain unclear. We characterized the soluble mucosal proteome associated with elevated cytokine expression in the female reproductive tract. A scoring system was devised based on the elevation (upper quartile) of at least three of seven inflammatory cytokines in cervicovaginal lavage. Using this score, HIV-uninfected Kenyan women were classified as either having… CONTINUE READING