Increased levels of circulating DNA in patients with systemic autoimmune diseases: A possible marker of disease activity in Sjögren's syndrome.

@article{Bartoloni2011IncreasedLO,
  title={Increased levels of circulating DNA in patients with systemic autoimmune diseases: A possible marker of disease activity in Sj{\"o}gren's syndrome.},
  author={E Bocci Bartoloni and Vienna Ludovini and Alessia Alunno and Lorenza Pistola and Onelia Bistoni and Lucio Crin{\`o} and Roberto Gerli},
  journal={Lupus},
  year={2011},
  volume={20 9},
  pages={928-35}
}
High levels of serum and/or plasma circulating DNA (cDNA) have been described in patients with systemic autoimmune diseases (SADs). However, the role of this molecule has not been clarified. Our aim was to evaluate plasma cDNA levels in 48 systemic lupus erythematosus (SLE) and 44 primary Sjögren's syndrome (SS) patients, as compared with healthy and rheumatoid arthritis (RA) subjects, and to analyse their correlation with disease activity, disease damage and clinical manifestations. Plasma DNA… CONTINUE READING

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