Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.

@article{Parikh2014IncreasedLO,
  title={Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection.},
  author={Rushi V. Parikh and Rebecca C. Scherzer and Elaine M Nitta and Anna M. Leone and Sophia Hur and Vanita R. Mistry and John S. Macgregor and Jeffrey N Martin and Steven G. Deeks and Patricia Ganz and Priscilla Ying Hsue},
  journal={AIDS},
  year={2014},
  volume={28 4},
  pages={
          511-9
        }
}
OBJECTIVE To examine the relationship between asymmetric dimethylarginine (ADMA) and HIV-associated pulmonary arterial hypertension (PAH). DESIGN HIV infection is an independent risk factor for PAH, but the underlying pathogenesis remains unclear. Chronic inflammation resulting in nitric oxide-mediated endothelial dysfunction is a key mechanism underlying other types of PAH. ADMA is an endogenous inhibitor of endothelial nitric oxide synthase. Among uninfected individuals, ADMA is associated… CONTINUE READING
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