Increased levels of alpha6 integrins are associated with the metastatic phenotype of human breast cancer cells.

@article{Mukhopadhyay1999IncreasedLO,
  title={Increased levels of alpha6 integrins are associated with the metastatic phenotype of human breast cancer cells.},
  author={Ratna Mukhopadhyay and Rachel Leigh Theriault and Janet E. Price},
  journal={Clinical & experimental metastasis},
  year={1999},
  volume={17 4},
  pages={325-32}
}
Integrins play an important role in interactions between cells and the extracellular matrix, and thus have a potential role in metastasis. Expression levels of alpha6, beta1 and beta4 integrin sub-units were measured in a panel of human breast cancer cell lines by RT/PCR, immunoprecipitation and flow cytometry. All the lines expressed alpha6, with the highest levels in the MDA-MB-231 and MDA-MB-435 cells. These grew the most aggressively and were metastastic in nude mice. Low levels of alpha6… CONTINUE READING

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