Increased levels of advanced glycation end products positively correlate with iron overload and oxidative stress markers in patients with β-thalassemia major

Abstract

The impaired biosynthesis of the β-globin chain in β-thalassemia leads to the accumulation of unpaired alpha globin chains, failure in hemoglobin formation, and iron overload due to frequent blood transfusion. Iron excess causes oxidative stress and massive tissue injuries. Advanced glycation end products (AGEs) are harmful agents, and their production… (More)
DOI: 10.1007/s00277-017-3223-3

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@article{Mirlohi2017IncreasedLO, title={Increased levels of advanced glycation end products positively correlate with iron overload and oxidative stress markers in patients with β-thalassemia major}, author={Maryam Sadat Mirlohi and Hamid Yaghooti and Saeed Shirali and Ali Aminasnafi and Samaneh Olapour}, journal={Annals of Hematology}, year={2017}, pages={1-6} }