Increased levels of Dickkopf-1 are indicative of Wnt/β-catenin downregulation and lower osteoblast signaling in children and adolescents with type 1 diabetes mellitus, contributing to lower bone mineral density

Abstract

Higher levels of Dickkopf-1, which is an inhibitor of Wnt/β-catenin bone metabolic pathway, could be indicative of downregulated Wnt system, with possible lower osteoblast activation and higher osteoclast signaling in type 1 diabetes mellitus children and adolescents. Dickkopf-1 could significantly contribute to diabetes osteopathy. Increased fracture risk… (More)
DOI: 10.1007/s00198-016-3802-5

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@article{Tsentidis2016IncreasedLO, title={Increased levels of Dickkopf-1 are indicative of Wnt/β-catenin downregulation and lower osteoblast signaling in children and adolescents with type 1 diabetes mellitus, contributing to lower bone mineral density}, author={C Tsentidis and Dimitrios I Gourgiotis and Lydia Kossiva and Antonios S Marmarinos and Artemis E. Doulgeraki and Kyriaki A Karavanaki}, journal={Osteoporosis International}, year={2016}, volume={28}, pages={945-953} }