Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection.

@article{Hamlyn2012IncreasedLO,
  title={Increased levels of CD4 T-cell activation in individuals with CXCR4 using viruses in primary HIV-1 infection.},
  author={Elizabeth Hamlyn and Stephen Hickling and Kholoud Porter and John A. Frater and Rodney Phillips and Mark J. Robinson and Nicola E Mackie and Steve Kaye and Myra Mcclure and Sarah Fidler},
  journal={AIDS},
  year={2012},
  volume={26 7},
  pages={887-90}
}
CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more… CONTINUE READING
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