Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue

@article{Tang2005IncreasedLO,
  title={Increased level of polymerase III transcribed Alu RNA in hepatocellular carcinoma tissue},
  author={Rui-bao Tang and Hong-Yang Wang and Hai-ying Lu and Jun Xiong and Hong-hua Li and Xiu-hua Qiu and Hou-qi Liu},
  journal={Molecular Carcinogenesis},
  year={2005},
  volume={42}
}
There have been extensive observations that RNA containing repetitive elements accumulates in transformed cells and tumor tissues. In the present study, we first obtained result consistent with previous observations by in situ hybridization. Then we used primer extension analysis to determine the level of polymerase III directed Alu RNA and found an increased expression of Alu RNA in hepatocellular carcinoma. © 2004 Wiley‐Liss, Inc. 
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The impacts of Alu DNA sequences that are in close proximity to genes, Pol-III-transcribed free Alu RNAs, and Pol-II- transcribed AluRNAs that are embedded within coding or noncoding RNA transcripts are discussed.
Multiple Roles of Alu-Related Noncoding RNAs.
  • A. Berger, K. Strub
  • Biology, Medicine
    Progress in molecular and subcellular biology
  • 2011
Repetitive Alu and Alu-related elements are present in primates, tree shrews (Scandentia), and rodents and have expanded to 1.3 million copies in the human genome by nonautonomous retrotransposition.
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