Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers

@article{Hidaka2010IncreasedLR,
  title={Increased leukocyte rho kinase (ROCK) activity and endothelial dysfunction in cigarette smokers},
  author={Takayuki Hidaka and Takaki Hata and Junko Soga and Yuichi Fujii and Naomi Idei and Noritaka Fujimura and Yasuki Kihara and Kensuke Noma and James K. Liao and Yukihito Higashi},
  journal={Hypertension Research},
  year={2010},
  volume={33},
  pages={354-359}
}
Rho-associated kinases (ROCKs) have been shown to be involved in the pathogenesis of atherosclerosis. Although smoking is associated with endothelial dysfunction and ROCK inhibitors improve endothelial function in smokers, it is not known whether ROCK activity is increased in smokers and whether this correlates with endothelial dysfunction. The purpose of this study was to evaluate the relationship between ROCK activity and endothelial function in smokers. We evaluated flow-mediated… CONTINUE READING
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