Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy

@article{Darabi2011IncreasedLA,
  title={Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy},
  author={Maryam Darabi and Mohammed Rabbani and Mohsen Ani and Elahe Zarean and Mojtaba Panjehpour and Ahmad Movahedian},
  journal={Gynecological Endocrinology},
  year={2011},
  volume={27},
  pages={701 - 705}
}
Objective. The ATP binding cassette A1 (ABCA1) is a key participant in the reverse cholesterol process whereby mediates cholesterol efflux directly to HDL particles. The aim of this study was to investigate whether long-term treatment with conventional hormone replacement therapy (HRT) in post-menopausal women could affect their leukocytes ABCA1 expression. Changes in various serum lipids and lipoprotein fractions were also investigated. Material and Methods. A total of 60 non-obese… 
Atorvastatin and hormone therapy influence expression of ABCA1, APOA1 and SCARB1 in mononuclear cells from hypercholesterolemic postmenopausal women
TLDR
Basal ABCA1 and SCARB1 expression profile could be helpful markers in predicting the effect of atorvastatin and HT on RCT, according to the changes in apoAI levels in this sample population of postmenopausal women.
Profound Changes in Sex Hormone Levels during Cross-Sex Hormone Therapy of Transsexuals do not Alter Serum Cholesterol Acceptor Capacity.
TLDR
Data from this study further challenge the traditional view that estrogen and testosterone exert beneficial and detrimental effects, respectively, on lipoprotein metabolism and ultimately atherosclerosis.
Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/β2-glycoprotein I complexes in postmenopausal women.
TLDR
It is indicated that HRT in postmenopausal women leads to an increase in TAC without an equivalent change in serum levels of oxLDL/β2GPI complexes, and beneficial effects of HRT could be explained by improving antioxidant status, but may not be directly associated with a change in oxidized lipoprotein production.
Lack of association between circulating levels of oxidized LDL/β2-glycoprotein I complexes and leukocyte ABCA1 gene expression
TLDR
The data demonstrated the lack of any significant association between ABCA1 expression and increased levels of oxLDL/b2GPI, serving as an integrative marker for systemic oxidative stress, which may be important to understand the relation of oxidative stress with dyslipidemia and cardiovascular disease.
Carbohydrate intake modulates the effect of the ABCA1-R230C variant on HDL cholesterol concentrations in premenopausal women.
TLDR
The effect of the ABCA1-R230C gene variant on HDL-C concentrations is modulated by carbohydrate intake in premenopausal women, and this finding may help design optimized dietary interventions according to sex and ABCA 1-R 230C genotype.
Carbohydrate Intake Modulates the Effect of the ABCA 1R 230 C Variant on HDL Cholesterol Concentrations in Premenopausal Women 1 , 2
The R230C variant of the ATP-binding cassette transporter A1 (ABCA1) gene has been consistently associated with decreased HDL-cholesterol (HDL-C) concentrations in several studies in the Mexican
Dietary fat and carbohydrate modulate the effect of the ATP-binding cassette A1 (ABCA1) R230C variant on metabolic risk parameters in premenopausal women from the Genetics of Atherosclerotic Disease (GEA) Study
TLDR
This is the first study reporting a gender-specific interaction between ABCA1/R230C variant and dietary carbohydrate and fat percentages affecting VAT/SAT ratio, GGT, ALP, adiponectin levels and HOMA index and shows how gene-environment interactions may help further understand how certain gene variants confer metabolic risk.
17β-estradiol suppresses the macrophage foam cell formation associated with SOCS3.
  • X. Liang, M. He, +6 authors Z. Yuan
  • Biology, Medicine
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2013
TLDR
E2 reduces atherosclerosis in ApoE null mice associated with upregulating ABCA1 expression and modulating the cholesterol efflux, which are dependent on SOCS3 upregulation.
Sex Hormones and Their Receptors Regulate Liver Energy Homeostasis
TLDR
The role of estrogens and androgens and the mechanisms through which estrogen receptors and androgen receptors regulate lipid and glucose metabolism in the liver are discussed and sex hormone receptors could be potential promising targets for the prevention of hepatic steatosis.
The ABCA1 Gene R230C Variant Is Associated with Decreased Risk of Premature Coronary Artery Disease: The Genetics of Atherosclerotic Disease (GEA) Study
TLDR
C230 was associated with both decreased HDL-C levels and a lower risk of premature CAD, and gender-specific BMI-R230C interactions were observed for different metabolic traits, indicating the need to further analyze interactions of this functional and frequent variant with diet, exercise and other environmental factors.
...
1
2
...

References

SHOWING 1-10 OF 34 REFERENCES
Role of the Estrogen and Progestin in Hormonal Replacement Therapy on Apolipoprotein A-I Kinetics in Postmenopausal Women
TLDR
Postmenopausal estrogen replacement increases apoA-I levels and production rate, and when progestin is added to estrogen, it opposes these effects by reducing the production of apo A-I.
Effects of hormonal replacement therapy on lipid and haemostatic factors in post-menopausal ESRD patients.
TLDR
It is suggested that HRT has favourable effects on atherosclerosis risk parameters in post- menopausal women with ESRD as in the general population of post-menopausal women.
Increased activity of lecithin:cholesterol acyltransferase during short-term oral estrogen progestin replacement therapy in a group of postmenopausal women.
TLDR
It is indicated that short-term estrogen-progestin therapy produces a significant increase in plasma LCAT activity, as well as beneficial changes in the lipid profile, in postmenopausal women.
Sequential estrogen-progestin replacement therapy in healthy postmenopausal women: effects on cholesterol efflux capacity and key proteins regulating high-density lipoprotein levels.
TLDR
It is shown that HRT not only modifies HDL-cholesterol level, but also its lipid composition and HDL lipoparticle distribution, and decreases the activity of PLTP, a key protein regulating HDL levels.
The effects of estrogen administration on plasma lipoprotein metabolism in premenopausal females.
TLDR
The effects of estrogen administration on plasma lipoprotein metabolism were investigated in five normolipidemic premenopausal females and data are consistent with the concept that estrogen administration at the dose level studied in pre menopausal females causes significant elevations in VLDL and HDL constituents, associated with enhanced production of VLDB and HDL apoA-I.
Effects of continuous conjugated estrogen and micronized progesterone therapy upon lipoprotein metabolism in postmenopausal women.
TLDR
The major conclusion is that increased fractional catabolism of LDL underlies the LDL-lowering effect of the combined hormones.
ABCA1 Expression in Carotid Atherosclerotic Plaques
TLDR
Despite significant upregulation of ABCA1 mRNA, possibly mediated via LXRα,ABCA1 protein is markedly reduced in advanced carotid atherosclerotic lesions, suggesting the plaque microenvironment may contribute to the differential ABCA 1 expression.
Effects of post-menopausal oestrogen-progestogen replacement therapy on serum lipids and lipoproteins: a review.
TLDR
It appears that many progestogens are capable of diminishing the beneficial changes induced by oestrogens, and the ultimate effect depends on the type and daily dose of both the oestrogen and the progestogen component.
Effect of postmenopausal hormone therapy on lipoprotein(a) concentration. PEPI Investigators. Postmenopausal Estrogen/Progestin Interventions.
TLDR
Changes in Lp(a) associated with hormone therapy were positively correlated with changes in LDL cholesterol, total cholesterol, apolipoprotein B, and fibrinogen levels and were similar across subgroups defined by age, weight, ethnicity, and prior hormone use.
Estrogen-induced regulation of the ATP-binding cassette transporter A1 (ABCA1) in mice: A possible mechanism of atheroprotection by estrogen
  • R. Srivastava
  • Biology, Medicine
    Molecular and Cellular Biochemistry
  • 2004
TLDR
Data show for the first time that estrogen's antiatherogenic effects may occur via ABCA1-mediated pathway, and circulating HDL levels may influence expression ofABCA1.
...
1
2
3
4
...