Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis.

@article{Zhu2005IncreasedLO,
  title={Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis.},
  author={Xinsheng Zhu and Oliver Y. Bernecker and Naveen S Manohar and Roger J. Hajjar and Judith Hellman and Fumito Ichinose and H{\'e}ctor H. Valdivia and Ulrich Schmidt},
  journal={Critical care medicine},
  year={2005},
  volume={33 3},
  pages={598-604}
}
OBJECTIVE Changes in cardiac function due to sepsis have been widely reported. However, the underlying mechanisms remain poorly understood. In the mammalian heart, myocyte function and intracellular calcium homeostasis are closely coupled. In this study we tested the hypothesis that alterations in cardiac calcium homeostasis due to sepsis underlie the observed myocyte dysfunction. DESIGN Randomized prospective animal study. SETTING Research laboratory. SUBJECTS Male Sprague-Dawley rats… CONTINUE READING