Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.

@article{Lowe2012IncreasedLS,
  title={Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice.},
  author={John S. Lowe and Dina Myers Stroud and Tao Yang and Lynn S Hall and Thomas C. Atack and Dan M. Roden},
  journal={Cardiovascular research},
  year={2012},
  volume={95 3},
  pages={300-7}
}
AIMS Female gender is a risk factor for long QT-related arrhythmias, but the underlying mechanisms remain uncertain. Here, we tested the hypothesis that gender-dependent function of the post-depolarization 'late' sodium current (I(Na-L)) contributes. METHODS AND RESULTS Studies were conducted in mice in which the canonical cardiac sodium channel Scn5a locus was disrupted, and expression of human wild-type SCN5A cDNA substituted. Baseline QT intervals were similar in male and female mice, but… CONTINUE READING

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Female gender: risk factor for congenital long QT-related arrhythmias.

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Effects of late sodium current enhancement during LQT-related arrhythmias. A simulation study

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology • 2010
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