Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells.

@article{Tiefenthaler2001IncreasedLP,
  title={Increased lactate production follows loss of mitochondrial membrane potential during apoptosis of human leukaemia cells.},
  author={Martin Tiefenthaler and Albert Amberger and Nicole Bacher and Bernd L. Hartmann and Raimund Margreiter and Reinhard Kofler and Guenther Konwalinka},
  journal={British journal of haematology},
  year={2001},
  volume={114 3},
  pages={574-80}
}
Acute tumour-lysis syndrome (ATLS) is a frequently fatal complication after cytoreductive leukaemia therapy. Lactic acidosis is associated with ATLS and its extent is correlated with the severity of ATLS. In the course of cytoreductive therapy, apoptosis is induced in tumour cells, which results in loss of mitochondrial function. We hypothesize that loss of mitochondrial function leads to compensatory glycolysis, which is the main cause of lactate accumulation and acidosis. We tested this… CONTINUE READING
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