Increased islet volume but unchanged islet number in ob/ob mice.

@article{Bock2003IncreasedIV,
  title={Increased islet volume but unchanged islet number in ob/ob mice.},
  author={Troels G Bock and Bente Pakkenberg and Karsten Buschard},
  journal={Diabetes},
  year={2003},
  volume={52 7},
  pages={
          1716-22
        }
}
It is important for our understanding of the pancreatic islets to study whether new islets are able to form in the intact pancreas. We developed a new method to determine the total number and the mean volume of the pancreatic islets, and we used this method to study the expansion of the islet mass in ob/ob mice (n = 8), using ob/+ mice (n = 8) as controls. The total islet volume was increased by a factor of 3.6 in ob/ob mice compared with ob/+ mice, whereas, importantly, the total number of… CONTINUE READING
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