Increased islet viability by addition of beraprost sodium to collagenase solution.

@article{Arita2001IncreasedIV,
  title={Increased islet viability by addition of beraprost sodium to collagenase solution.},
  author={Seiji Arita and S Une and Shoji Ohtsuka and Toshiyasu Kawahara and A Kasraie and Craig V Smith and Yoko S Mullen},
  journal={Pancreas},
  year={2001},
  volume={23 1},
  pages={62-7}
}
The digestion of pancreatic tissue with collagenase is an essential part of the islet isolation procedure. However, the process exposes islets to various types of harmful factors, including collagenase contaminants, enzymes released from the acinar cells, warm ischemia, and mechanical agitation. Nitrogen oxide production and cytokine release may also contribute to islet cell damage. Protection of islets from such damage would improve the islet yield, survival, and function. Beraprost sodium… CONTINUE READING

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