Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.

@article{Smith2010IncreasedIA,
  title={Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment.},
  author={Mark A. Smith and Xiongwei Zhu and Massimo Tabaton and Gang Liu and Daniel W. McKeel and Mark L. Cohen and Xinglong Wang and Sandra Siedlak and Barney E. Dwyer and Takaaki Hayashi and Masao Nakamura and Akihiko Nunomura and George Perry},
  journal={Journal of Alzheimer's disease : JAD},
  year={2010},
  volume={19 1},
  pages={
          363-72
        }
}
It is now established that oxidative stress is one of the earliest, if not the earliest, change that occurs in the pathogenesis of Alzheimer's disease (AD). Consistent with this, mild cognitive impairment (MCI), the clinical precursor of AD, is also characterized by elevations in oxidative stress. Since such stress does not operate in vacuo, in this study we sought to determine whether redox-active iron, a potent source of free radicals, was elevated in MCI and preclinical AD as compared to… CONTINUE READING

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