Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.

@article{Martins2009IncreasedIB,
  title={Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen.},
  author={Vera L{\'u}cia Campos Martins and Jashmin J Vyas and Mei Chen and Karin Purdie and Charles A. Mein and Andrew P South and Alan Storey and John A. McGrath and E A O'Toole},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 11},
  pages={
          1788-99
        }
}
Type VII collagen (ColVII) is the main component of anchoring fibrils, attachment structures within the lamina densa of the basement membrane that are responsible for attachment of the epidermis to the dermis in skin. Mutations in the human ColVII gene, COL7A1, cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae, associated with a greatly increased risk of skin cancer. In this study, we examined the effect of loss of ColVII… CONTINUE READING

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