Increased intrapancreatic trypsinogen activation in ischemia-induced experimental pancreatitis.

  title={Increased intrapancreatic trypsinogen activation in ischemia-induced experimental pancreatitis.},
  author={Kai Mithoefer and Carlos Fern{\'a}ndez-del Castillo and Theodore W. Frick and Thomas Foitzik and Dilip Bassi and Kent B. Lewandrowski and David W. Rattner and Andrew Louis Warshaw},
  journal={Annals of surgery},
  volume={221 4},
OBJECTIVE The potential of pancreatic ischemia to cause acute pancreatitis as indicated by morphologic changes and ectopic trypsinogen activation was investigated. BACKGROUND Experimental evidence has shown that pancreatic ischemia is important in the evolution of severe pancreatitis, but whether ischemia can initiate pancreatitis has been disputed. METHODS Pancreatic ischemia was induced in rats by hemorrhagic hypotension (30 mm Hg for 30 min; n = 64). Changes of pancreatic… CONTINUE READING

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