Increased intrahepatic and circulating levels of endoglin, a TGF-beta1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis.

@article{Clemente2006IncreasedIA,
  title={Increased intrahepatic and circulating levels of endoglin, a TGF-beta1 co-receptor, in patients with chronic hepatitis C virus infection: relationship to histological and serum markers of hepatic fibrosis.},
  author={M Clemente and Oscar N{\'u}{\~n}ez and Raquel Lorente and Diego Rinc{\'o}n and Ana M Matilla and Magdalena Salcedo and Mar{\'i}a Vega Catalina and C. S. Ripoll and Oreste lo Iacono and Rafael Ba{\~n}ares and Gerardo Clemente and Carmelo Garc{\'i}a-Monz{\'o}n},
  journal={Journal of viral hepatitis},
  year={2006},
  volume={13 9},
  pages={625-32}
}
Endoglin, a transforming growth factor (TGF)-beta1 co-receptor, has been associated with renal and cutaneous fibrosis, as overexpression of this protein has been observed in biopsies from patients with glomerulosclerosis and scleroderma, respectively. Our aim was to evaluate whether endoglin may be associated with hepatic fibrosis featuring chronic hepatitis C virus (HCV) infection. Fifty-two anti-HCV+ patients, five anti-HCV- patients and 27 healthy subjects were studied. Western blot and… CONTINUE READING

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