Increased intracranial pressure induces a rapid systemic interleukin-10 release through activation of the sympathetic nervous system.

@article{Woiciechowsky2005IncreasedIP,
  title={Increased intracranial pressure induces a rapid systemic interleukin-10 release through activation of the sympathetic nervous system.},
  author={Christian Woiciechowsky and Hans Dieter Volk},
  journal={Acta neurochirurgica. Supplement},
  year={2005},
  volume={95},
  pages={
          373-6
        }
}
There is a bi-directional communication between the immune and central nervous system. In this context, it is known that patients with traumatic brain injury suffered from systemic immunodepression and an increased risk to develop infectious complications. We investigated the role of an increased intracranial pressure (ICP) and sympathetic activation on systemic immune changes. A sustained increase in ICP was achieved by inflation of a subdural balloon. At different time points, plasma levels… CONTINUE READING

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