Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest.

@article{Tseng1999IncreasedIE,
  title={Increased intracerebral excitatory amino acids and nitric oxide after hypothermic circulatory arrest.},
  author={Elaine E. Tseng and Malcolm V. Brock and Christopher C Kwon and M Annanata and Mary S Lange and Juan C Troncoso and Michael V Johnston and William A. Baumgartner},
  journal={The Annals of thoracic surgery},
  year={1999},
  volume={67 2},
  pages={371-6}
}
BACKGROUND Prolonged hypothermic circulatory arrest (HCA) results in neurologic injury, but the mechanism of this injury is unknown. This study was undertaken to measure quantitatively intracerebral excitatory amino acids and citrulline, an equal coproduct of nitric oxide, during HCA. We hypothesized that HCA resulted in higher levels of glutamate, aspartate, glycine, causing increased intracellular calcium, and therefore, nitric oxide and citrulline. METHODS Ten dogs underwent intracerebral… CONTINUE READING
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