Increased intracellular cyclic AMP levels suppress the mitogenic responses of human astrocytoma cells to growth factors

@article{Tsai1995IncreasedIC,
  title={Increased intracellular cyclic AMP levels suppress the mitogenic responses of human astrocytoma cells to growth factors},
  author={Chon-haw Tsai and Li-man Hung and H W Cheng and J. Chen},
  journal={Journal of Neuro-Oncology},
  year={1995},
  volume={23},
  pages={41-52}
}
It has been shown that the intracellular cAMP levels were decreased in human malignant astrocytomas. On the other hand, various growth factors and their receptors were found to be overexpressed in these tumors. It is therefore intriguing as to whether there is interplay between the two phenomena in the modulation of the astrocytoma cell growth. In a basal… CONTINUE READING