Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients.

@article{Doig1998IncreasedIP,
  title={Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients.},
  author={C. Doig and L. Sutherland and J. Sandham and G. Fick and M. Verhoef and J. Meddings},
  journal={American journal of respiratory and critical care medicine},
  year={1998},
  volume={158 2},
  pages={
          444-51
        }
}
We conducted a prospective, observational cohort study designed to compare intestinal permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset of critically ill patients in an intensive care unit (ICU). All patients with an expected ICU stay of 72 h or more were entered into the study, and IP was determined on a daily basis whenever possible from the urinary fractional excretion of orally administered lactulose and mannitol (LMR). Forty-seven consecutive… Expand
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