Increased interstitial protein because of impaired lymph drainage does not induce fibrosis and inflammation in lymphedema.


OBJECTIVE The pathophysiology of lymphedema is incompletely understood. We asked how transcapillary fluid balance parameters and lymph flow are affected in a transgenic mouse model of primary lymphedema, which due to an inhibition of vascular endothelial growth factor receptor-3 (VEGFR-3) signaling lacks dermal lymphatics, and whether protein accumulation… (More)
DOI: 10.1161/ATVBAHA.112.300384


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