Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation

@inproceedings{Famenini2017IncreasedIM,
  title={Increased intermediate M1-M2 macrophage polarization and improved cognition in mild cognitive impairment patients on ω-3 supplementation},
  author={Sam Famenini and Elizabeth A. Rigali and Henry M. Olivera-Perez and Johnny Dang and Michael To Chang and Ramesh Chandra Halder and Rammohan V Rao and Matteo Pellegrini and Verna R Porter and Dale E. Bredesen and Milan Fiala},
  booktitle={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2017}
}
Monocyte/macrophages of patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) are defective in phagocytosis and degradation amyloid β1-42 (Aβ1-42), but are improved by ω-3 fatty acids (ω-3s). The hypothesis of this study was that active Aβ1-42 phagocytosis by macrophages prevents brain amyloidosis and thus maintains cognition. We studied the effects of self-supplementation with a drink with ω-3s, antioxidants, and resveratrol on Mini-Mental State Examination (MMSE) scores… CONTINUE READING