Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma.

@article{Cho2005IncreasedII,
  title={Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma.},
  author={Sang-Heon Cho and Luminita Aurelia Stanciu and Stephen T Holgate and Sebastian L. Johnston},
  journal={American journal of respiratory and critical care medicine},
  year={2005},
  volume={171 3},
  pages={
          224-30
        }
}
Increased Th2 cytokine production in asthma is widely accepted, but excess production by asthmatic human airway CD4(+) T cells has not been demonstrated, nor has a relationship with disease severity. The importance of airway CD8(+) T cell type 1 and type 2 cytokine production in asthma is unknown. We investigated frequencies of IFN-gamma, interleukin (IL)-4 and IL-5 producing CD4(+) and CD8(+) blood and sputum T cells from normal subjects and subjects with asthma and compared between cell… 
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References

SHOWING 1-10 OF 50 REFERENCES
Increased levels of IL-4 in CD8+ T cells in atopic asthma.
Cytokine profile of bronchoalveolar lavage-derived CD4(+), CD8(+), and gammadelta T cells in people with asthma after segmental allergen challenge.
TLDR
Findings indicate an increased Th2-cytokine profile in gammadelta T cells after allergen challenge, and the dysbalance between Th1 and Th2 cytokines was further accentuated by a reduction in Th1 cytokine-producing T cells.
Cytokine Profile of Bronchoalveolar Lavage–Derived CD4+, CD8+, and γδ T Cells in People with Asthma after Segmental Allergen Challenge
TLDR
The aim of the present study was to investigate the cytokine production potential of CD4+, CD8+, or γδ+ T cells derived from the bronchoalveolar space of mild atopic asthmatic subjects and nonatopic control subjects before and 24 h after segmental allergen challenge.
Phenotype of cells expressing mRNA for TH2-type (interleukin 4 and interleukin 5) and TH1-type (interleukin 2 and interferon gamma) cytokines in bronchoalveolar lavage and bronchial biopsies from atopic asthmatic and normal control subjects.
TLDR
It is shown that CD3+ T cells are the most abundant cells expressing IL-4 and IL-5 mRNA in BAL and BX from allergic asthma, and fewer, but detectable, numbers of tryptase+ mast cells and EG2+ eosinophils also expressed these transcripts.
T-cell cytokine profile evaluated at the single cell level in BAL and blood in allergic asthma.
TLDR
The findings indicate that IL-4 production is confined to a relatively small proportion of airway and blood T-cells in asthma and that there is selective enhancement of IFN-gamma production by airway T- cells in asthma.
CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status.
TLDR
The serum concentrations of interferon-gamma and soluble IL-2R were significantly elevated in patients with acute severe asthma as compared with all the control groups and decreased as the patients improved clinically during the first 3-day period of hospital treatment.
Decreased frequency of interferon-gamma- and interleukin-2-producing cells in patients with atopic diseases measured at the single cell level.
Assessment of the Th1/Th2 paradigm in whole blood in atopy and asthma. Increased IFN-gamma-producing CD8(+) T cells in asthma.
TLDR
Results show that in addition to the well-known Th2 inflammation in asthma, there are IFN-gamma-producing CD8(+) T cells in the blood, possibly controlled by IL-12.
Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics.
TLDR
In atopic and nonatopic asthma CD8+ T cells, in addition to CD4+ T Cells, mast cells and eosinophils express mRNA for IL-4 and IL-5, a discrepancy may be partly attributable to the relative insensitivity of double IHC technique that does not allow detection of cytokine protein in T cells where, unlike eos inophils and mast cells, there is no facility for storage and concentration in granules.
Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy subjects.
TLDR
The results suggest that the clones from the asthmatic patients' bronchoalveolar lavage were derived from a more differentiated T-cell population, and local conditions in the airways may be involved in directing the cytokine production of T-cells.
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