Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome.

@article{Maeno2004IncreasedIE,
  title={Increased interleukin-18 expression in bone marrow of a patient with systemic juvenile idiopathic arthritis and unrecognized macrophage-activation syndrome.},
  author={Nobuaki Maeno and Syuji Takei and Hiroyuki Imanaka and Kimie Yamamoto and Kazumi Kuriwaki and Yoshifumi Kawano and Hiroshi Oda},
  journal={Arthritis and rheumatism},
  year={2004},
  volume={50 6},
  pages={1935-8}
}
The aberrant induction of proinflammatory cytokines is considered to be crucial in the pathogenesis of systemic juvenile idiopathic arthritis and adult-onset Still's disease. Interleukin-18 (IL-18) in particular has been reported to be a candidate for the key cytokine in both diseases; however, the origin of IL-18 is unclear. To clarify the origin, we investigated specimens from various organs obtained during autopsy of a child with systemic JIA and macrophage activation syndrome, using… CONTINUE READING

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