Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?

@article{Muranski2006IncreasedIL,
  title={Increased intensity lymphodepletion and adoptive immunotherapy—how far can we go?},
  author={Pawel Muranski and Andrea Boni and Claudia Wrzesinski and Deborah Citrin and Steven A Rosenberg and Richard Childs and Nicholas P Restifo},
  journal={Nature Clinical Practice Oncology},
  year={2006},
  volume={3},
  pages={668-681}
}
Experimental data indicate that lymphodepletion prior to adoptive transfer of tumor specific T-lymphocytes plays a key role in enhancing treatment efficacy by eliminating regulatory T-cells and competing elements of the immune system. Newly emerging animal data suggest that more profound lymphoablative conditioning with autologous hematopoetic stem-cell rescue might further enhance treatment results. The authors review the recent advances in adoptive immunotherapy of solid tumors and discuss… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 129 CITATIONS, ESTIMATED 61% COVERAGE

Cancer Supportive Care: Advances in Therapeutic Strategies

Gary H. Lyman, Jeffrey Crawford
  • 2008
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 2 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 115 REFERENCES

Dose response and factors related to interstitial pneumonitis after bone marrow transplant.

  • International journal of radiation oncology, biology, physics
  • 2005
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

CD8+ T-cell memory in tumor immunology and immunotherapy

CA Klebanoff
  • Immunol Rev
  • 2006

Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2006