Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice.

@article{Dominici2002IncreasedIS,
  title={Increased insulin sensitivity and upregulation of insulin receptor, insulin receptor substrate (IRS)-1 and IRS-2 in liver of Ames dwarf mice.},
  author={Fernando Pablo Dominici and Steven A. Hauck and Danila Paula Argentino and Andrzej Bartke and Daniel Turyn},
  journal={The Journal of endocrinology},
  year={2002},
  volume={173 1},
  pages={81-94}
}
In the present study we have used hypopituitary Ames dwarf mice, which lack GH, prolactin and TSH, to investigate the consequences of the deficiency of these hormones on glucose homeostasis and on the initial components of the insulin signal transduction pathway in the liver. Ames dwarf mice displayed hypersensitivity to insulin since they maintained lower fasting glucose concentrations (73% of control values), had significantly reduced amounts of insulin (58% of control values), and exhibited… CONTINUE READING
77 Citations
56 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 77 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 56 references

Effect of growth hormone on carbohydrate and lipid metabolism

  • MB Davidson
  • Endocrine Reviews
  • 1987
Highly Influential
4 Excerpts

A new dwarf mouse

  • R Schaible, JW Gowen
  • Genetics
  • 1961
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…