Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

@article{Elchebly1999IncreasedIS,
  title={Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.},
  author={Mounib Elchebly and Paul Payette and Eva Michaliszyn and Wanda A Cromlish and Sheila Collins and Ailsa Lee Loy and Denis Normandin and Alan Nai-Jen Cheng and Jean Himms-Hagen and C C Chan and Chidambaram Ramachandran and Michael J. Gresser and Michel L Tremblay and Brian P. Kennedy},
  journal={Science},
  year={1999},
  volume={283 5407},
  pages={1544-8}
}
Protein tyrosine phosphatase-1B (PTP-1B) has been implicated in the negative regulation of insulin signaling. Disruption of the mouse homolog of the gene encoding PTP-1B yielded healthy mice that, in the fed state, had blood glucose concentrations that were slightly lower and concentrations of circulating insulin that were one-half those of their PTP-1B+/+ littermates. The enhanced insulin sensitivity of the PTP-1B-/- mice was also evident in glucose and insulin tolerance tests. The PTP-1B… CONTINUE READING
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