Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity.

@article{Caprio1989IncreasedIS,
  title={Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity.},
  author={Sonia Caprio and G. Plewe and Michael Peter Diamond and Donald C Simonson and Susan D Boulware and Robert S. Sherwin and William V Tamborlane},
  journal={The Journal of pediatrics},
  year={1989},
  volume={114 6},
  pages={
          963-7
        }
}
Recent studies have suggested that insulin action is reduced during puberty in normal children. To determine whether such resistance leads to excessive insulin secretion, we used the hyperglycemic clamp technique to produce a standard hyperglycemic stimulus (125 mg/dl above fasting levels for 120 minutes) in 9 preadolescent and 14 adolescent healthy children and in 14 normal adults. Fasting plasma insulin and C-peptide concentrations were higher in adolescents than in preadolescents and adults… CONTINUE READING

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