Increased insulin action in SKIP heterozygous knockout mice.

  title={Increased insulin action in SKIP heterozygous knockout mice.},
  author={Takeshi Ijuin and Y Eugene Yu and Kiyohito Mizutani and Annie Y. Pao and Sanshiro Tateya and Yoshikazu Tamori and Allan Bradley and Tadaomi Takenawa},
  journal={Molecular and cellular biology},
  volume={28 17},
Insulin controls glucose homeostasis and lipid metabolism, and insulin impairment plays a critical role in the pathogenesis of diabetes mellitus. Human skeletal muscle and kidney enriched inositol polyphosphate phosphatase (SKIP) is a member of the phosphatidylinositol 3,4,5-trisphosphate phosphatase family (T. Ijuin et al. J. Biol. Chem. 275:10870-10875, 2000; T. Ijuin and T. Takenawa, Mol. Cell. Biol. 23:1209-1220, 2003). Previous studies showed that SKIP negatively regulates insulin-induced… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 16 extracted citations


Publications referenced by this paper.
Showing 1-10 of 32 references

The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2.

The international journal of biochemistry & cell biology • 2005

Similar Papers

Loading similar papers…