Increased inflammatory responses of persons of blood group O to Helicobacter pylori.

@article{Alkout2000IncreasedIR,
  title={Increased inflammatory responses of persons of blood group O to Helicobacter pylori.},
  author={Abdulhamid M Alkout and C. Caroline Blackwell and Donald Mackay Weir},
  journal={The Journal of infectious diseases},
  year={2000},
  volume={181 4},
  pages={1364-9}
}
Persons of blood group O are at increased risk of peptic ulcers. Enhanced binding of Helicobacter pylori to epithelial cells of persons of blood group O has been demonstrated. Release of interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-alpha by human leukocytes from 40 donors (10 from each ABO blood group) was measured after incubation in vitro with outer membrane protein preparations of H. pylori. Isolates DU (from a patient with a duodenal ulcer), GC (from a patient with gastric… CONTINUE READING
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